[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/betterbones.com\/bone-drugs\/bisphosphonates-make-bones-weaker\/#Article","mainEntityOfPage":"https:\/\/betterbones.com\/bone-drugs\/bisphosphonates-make-bones-weaker\/","headline":"Bisphosphonates make bones weaker, not stronger","name":"Bisphosphonates make bones weaker, not stronger","description":"Print PDF eBook Facebook Twitter Gmail LinkedIn Pinterest I\u2019ve argued for years that bisphosphonates \u2014 the knee-jerk bone drugs \u00a0recommended for those with osteoporosis regardless of their actual fracture risk \u2014 quite often offer no benefit to those who are prescribed them, and for many, do more harm than good. That’s why I was alarmed, […]","datePublished":"2018-04-03","dateModified":"2026-04-22","author":{"@type":"Person","@id":"https:\/\/betterbones.com\/author\/brownbetterbonesgmail-com\/#Person","name":"Dr. Susan E. Brown, PhD","url":"https:\/\/betterbones.com\/author\/brownbetterbonesgmail-com\/","identifier":72,"image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/8e08d87bd45250c6616e1752933a6576aba077f335d97ee337a0cde5e435cbd3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8e08d87bd45250c6616e1752933a6576aba077f335d97ee337a0cde5e435cbd3?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Center for Better Bones","logo":{"@type":"ImageObject","@id":"https:\/\/betterbones.com\/wp-content\/uploads\/2018\/12\/Better-Bones-AMP.png","url":"https:\/\/betterbones.com\/wp-content\/uploads\/2018\/12\/Better-Bones-AMP.png","width":150,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/betterbones.com\/wp-content\/uploads\/2018\/04\/bisphosphonates-BB-Blog-4-20-1.jpg","url":"https:\/\/betterbones.com\/wp-content\/uploads\/2018\/04\/bisphosphonates-BB-Blog-4-20-1.jpg","height":1109,"width":2120},"url":"https:\/\/betterbones.com\/bone-drugs\/bisphosphonates-make-bones-weaker\/","about":["Bone Drugs"],"wordCount":564,"keywords":["biphosphonates"],"articleBody":" Print PDF eBook\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tFacebook\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tTwitter\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tGmail\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tLinkedIn\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tPinterest\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tI\u2019ve argued for years that bisphosphonates \u2014 the knee-jerk bone drugs \u00a0recommended for those with osteoporosis regardless of their actual fracture risk \u2014 quite often offer no benefit to those who are prescribed them, and for many, do more harm than good. That’s why I was alarmed, but not surprised, by a recent study that found bisphosphonate drugs may be leaving bones weaker \u2014 not stronger \u2014 at the microscopic level (Ma et al, 2017).In the study, researchers obtained samples of trabecular bone from three groups of subjects: (1) normal, healthy older adults who had no fractures, (2) individuals who had fractured a bone after at least 1 year of treatment with bisphosphonates, and (3) individuals who\u2019d had fractures but were not being treated for osteoporosis.They first examined the bones\u2019 microstructure and identified areas of osteoclast activity (\u201cperforations\u201d) versus microscopic fractures (\u201cmicrocracks\u201d). Then they subjected each sample to load-controlled tensile testing to determine how much strain the bone could withstand.The results were revealing. The first group (no fractures) had the least amount of either perforations or microcracks. Both the second (untreated with fractures) and third (bisphosphonate-treated with fractures) groups had roughly equivalent amounts of perforations and microcracks. But the big difference was the volume of perforations versus microcracks: the untreated group had a significantly higher volume of perforations while the bisphosphonate group showed a significantly higher volume of microcracks.Bisphosphonates and bone fracture riskI\u2019ve always maintained that the greatest issue when it comes to bone health isn\u2019t thin bones \u2014 it\u2019s weak ones. In healthy bone, microfractures stimulate bone turnover, which ultimately renews bone and makes it stronger \u2014 unless the activity of bone-building osteoblasts is outstripped by bone-removing osteoclasts.It\u2019s pretty clear that the untreated patients who\u2019d had fractures were undergoing high bone turnover \u2014 that\u2019s why they had more (and larger) osteoclastic perforations. But the bisphosphonates-treated group had significantly larger microcracks \u2014 which suggests that in the bisphosphonate group, either the bone is much less resilient and more prone to cracking under strain than normal bone, or the usual repair mechanisms aren\u2019t working up to standard. Or both at the same time!More to the point, it suggests that people treated with bisphosphonates have bones that are significantly weaker and more prone to fracture than either healthy people or people with high bone turnover.The tensile strength testing performed on all three groups\u2019 samples confirmed this: Where the normal group had a tensile strength (measured in megapascals) of 1.62 MPa, the untreated fracture group\u2019s tensile strength was decreased by about 47% (to 0.86 MPa) \u2014 and the bisphosphonate group\u2019s tensile strength was an astonishing 64% (0.58 MPa) below the normal group\u2019s level.This means that people treated with bisphosphonates have much weaker bones than even people at high risk of fracture due to high bone turnover!So if using bisphosphonates leaves patients with slightly denser but significantly weaker bones, increasing the likelihood of a catastrophic fracture (never mind the other side effects), this leaves us asking, \u201cWhat exactly is their benefit?”Reference \u00a0Ma S, Goh EL, Jin A, et al. Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties. Sci Rep 2017;7:43399; DOI: 10.1038\/srep43399.Learn more about natural strategies in our guide to our natural approach to osteoporosis.For natural support alongside any treatment, read our complete guide to bone health nutrition as a natural foundation."},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Bone Drugs","item":"https:\/\/betterbones.com\/bone-drugs\/#breadcrumbitem"},{"@type":"ListItem","position":2,"name":"Bisphosphonates make bones weaker, not stronger","item":"https:\/\/betterbones.com\/bone-drugs\/bisphosphonates-make-bones-weaker\/#breadcrumbitem"}]}]